EPHect SOP for organoid models in endometriosis research

The EPHect Experimental Models (EPHect-EM) standard operating procedure provides a comprehensive overview of the strengths and limitations of organoid models that have been developed to study endometriosis. This detailed SOP is designed to aid both new and established investigators.

• EPHect-EM SOP for organoid models

EPHect-EM SOPs are also available for heterologous, homologous, and pain models.

Publications

• Elizabeth E Marr, Juan S Gnecco, Stacey A Missmer, Shannon M Hawkins, Kevin G Osteen, Lone Hummelshoj, Erin Greaves, and Kaylon L Bruner-Tran, for the EPHect-Experimental Models Working Group. WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research. Mol Hum Reprod 2025;31(3):Epub.
• Lone Hummelshoj, Daniëlle Peterse, Kaylon L Bruner-Tran, Stacey A Missmer, Erin Greaves. Enhancing collaboration in endometriosis research through the initiative of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect). Mol Hum Reprod 2025;31(3):Epub.

Acknowledgement

Investigators using EPHect tools are asked to include the following acknowledgment in all publications and presentations that utilise data collected using the EPHect questionnaires, forms, or sample collection protocols:
"Data collection was facilitated by and conducted in compliance with the Endometriosis Phenome and Biobanking Harmonisation Project (EPHect)."

Please also cite the above paper(s) whenever data collected utilising these protocols are published.

In addition, investigators whose data collection tools or methods included alterations to the EPHect standardised protocols are asked to describe those changes in the Methods section of manuscripts and when presenting their study results.

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